Cat Rambo lives, writes, and edits in the American Midwest. Their work has appeared in such places as Asimov's, Weird Tales, and Strange Horizons. They were the fiction editor of award-winning Fantasy Magazine (http://www.fantasy-magazine.com) and appeared on the World Fantasy Award ballot in 2012 for that work. Their story "Five Ways to Fall in Love on Planet Porcelain" was a 2012 Nebula Award finalist.

John Barth described Cat Rambo's writings as "works of urban mythopoeia" -- their stories take place in a universe where chickens aid the lovelorn, Death is just another face on the train, and Bigfoot gives interviews to the media on a daily basis. They has worked as a programmer-writer for Microsoft and a Tarot card reader, professions which, they claim, both involve a certain combination of technical knowledge and willingness to go with the flow. In 2005 she attended the Clarion West Writers' Workshop.

In 2007, their collaboration with Jeff VanderMeer, The Surgeon's Tale and Other Stories, appeared, while theri first solo collection, Eyes Like Sky and Coal and Moonlight, was published in August of 2009 and was an Endeavour Award finalist. In 2012, collection Near + Far appeared from Hydra House as well as a novella, A Seed Upon the Wind, as part of the Fathomless Abyss collaborative project. In 2023, their works DEVIL'S GUN and GODS OF TABAT will appear.

A frequent volunteer with the Science Fiction and Fantasy Writers of America, they are a former two-term president of the organization. Their most recent nonfiction work is writing book MOVING FROM IDEA TO FINISHED DRAFT (Plunkett Press).